The risk of chemical warfare (CW) has increased in recent years. The Homeland Security Enterprise (HSE) has a need to identify state and non-state actors likely to pursue the development of CW as well determining the factors that identify the use of CW. These factors include the states overall strategic orientation to CW, the types of CW agents likely to be pursued and the other activities that would accompany CW development.

The advancement of artificial intelligence (AI), including machine learning (ML) and increasingly autonomous systems, has resulted in a push for technical standards that can assess the trustworthiness of these technologies. Developing standards have the potential to drive the design and development of trustworthy systems, and to more cost-effectively evaluate AI-enabled systems during technology acquisition or regulation.

The risk of natural disasters and national emergencies drives the need for real-time decision-making to guide the allocation of critical resources and the design of resilient and effective supply chains to respond effectively to these events.

Securing the border between Ports-of-Entry (POEs) uses a variety of both physical and virtual infrastructure to detect, deter and disrupt pathways. The U.S. government is making substantial investments in both types of infrastructure to improve their capacity to prevent illegal smuggling and trafficking.

The COVID-19 pandemic has raised concerns on the state of biological warfare (BW) defense strategies. This includes identifying countries most likely to pursue the development of these BW capabilities, including the development of viable BW programs.